Apoptosis and breast cancer

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This is an open access article distributed under the terms of Creative Commons Attribution License. According to the statistics of the American Cancer Society, inthere were more thannew cases of breast cancer diagnosed in the United States, and approximately 40, patients died of breast cancer 1. It is estimated that one in eight women will develop breast cancer in their lifetime, and it is also estimated that approximately one in 37 women with breast cancer will die of the disease, most of whom are aged over 45 years.

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Breast cancer is the most common cancer type amongst women, accounting for most female cancer deaths second to cervical cancer worldwide. It is, therefore, highly crucial to understand the molecular biology and explore other pathways involved in carcinogenesis in order to select appropriate treatment not only for breast cancer but for other cancers as well. Cancer progression is favoured by DNA damage and in most cases a consequent disruption of the apoptotic pathway, thus leading to uncontrolled cell proliferation.

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Centratherum anthelminticum L. We recently reported anti-oxidant property of chloroform fraction of Centratherum anthelminticum L. However, the active compounds in CACF have not been investigated previously.

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This is an open access article distributed under the terms of Creative Commons Attribution License. Currently, treatment of BC primarily focuses on surgery, chemotherapy and endocrine therapy. However, the prognosis of BC treatment is not satisfactory, mainly due to progression and metastasis following conventional treatment 23.

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Breast cancer is affected by the immune system in that different cytokines play roles in its initiation and progression. Interleukin ILan anti-inflammatory cytokine, is an immunosuppressive factor involved in tumorigenesis. The present study was conducted to investigate the gene silencing effect of a small interference RNA siRNA targeting IL on the apoptotic pathway in breast cancer cell line.

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Aims: Several anticancer drugs are being currently used in the treatment of breast cancer; however, there is a need to develop newer therapeutic regimens that owing to higher cytotoxicity and lower resistance. This study was aimed to investigate the effect of pentoxifylline PTX in combination tamoxifen TAM on viability and apoptosis of breast cancer cell lines in vitro. Conclusion: PTX induced synergistic effect with TAM on cell growth inhibition of breast cancer cells and could be a candidate drug for breast cancer treatment.

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Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. Received 9 September Published 18 January Volume Pages —

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Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. Received 9 September

Cancer is one of the most leading causes of human death, worldwide, and breast cancer is the most common type of malignancy in women 1. In Iran, breast cancer ranks the first among cancers diagnosed in females with an increasing trend in the breast cancer related mortality rate in the recent decade 2. The growth and survival of cancer cells is correlated with a reduced level of genetically programmed cell death; the apoptosis 3. Therefore, cytotoxic agents which induce apoptosis in the cancer cells are used as anticancer chemotherapeutic agents 4.

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