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Despite the good responses of patients pts with stage III breast cancer to neoadjuvant chemotherapy NACmost eventually relapse and have a poor prognosis. Subsequent to the completion of NAC and surgery, we assessed the clinicopathological results and performed prognostic analyses. Statistical analyses concerning disease-free survival DFS or overall survival OS were conducted by a Cox proportional hazard model.
Section editors Gabriel Hortobagyi and Kathleen Pritchard have disclosed no financial relationships relevant to the content of this article. The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. Summarize the main risk factors for relapse in patients with T4 breast cancer after neoadjuvant chemotherapy.
Because these problems are much more common than IBC, your doctor might at first suspect infection as a cause and treat you with antibiotics. The possibility of IBC should be considered more strongly if you have these symptoms and are not pregnant or breastfeeding, or have been through menopause. IBC grows and spreads quickly, so the cancer may have already spread to nearby lymph nodes by the time symptoms are noticed.
Hearing you have stage 3 breast cancer can bring many questions — about your diagnosis, survival, treatments, and more. First, stage 3 breast cancer means your cancer has spread beyond the tumor and has possibly gone to lymph nodes and muscle, but has not spread to nearby organs. Doctors divide stage 3 into more specific categories 3A, 3B, and 3C and the cancer subtype, meaning which type of breast cancer you have.
Stage 3 means that the cancer has spread from the breast to lymph nodes close to the breast or to the skin of the breast or to the chest wall. Stage 3B means the tumour has spread to the skin of the breast or the chest wall. The cancer has made the skin break down an ulcer or caused swelling.
Stage 3 cancer means the breast cancer has extended to beyond the immediate region of the tumor and may have invaded nearby lymph nodes and muscles, but has not spread to distant organs. Although this stage is considered to be advanced, there are a growing number of effective treatment options. The difference is determined by the size of the tumor and whether cancer has spread to the lymph nodes and surrounding tissue. No actual tumor is associated with the cancerous cells or the tumor may be any size, AND the nearby lymph nodes 4 or more nodes with as many as 9 affected contain cancer.
An important part of diagnosing breast cancer is staging. Staging is the process of finding out how much cancer there is and where it is located. This information is used to plan cancer treatment and estimate a prognosis.